ABSTRACT
ABSTRACT Adenosquamous carcinoma of the pancreas (ASCP) is a rare variant of the pancreatic ductal adenocarcinoma (PDAC). Between 2004 and 2016, four cases of ASCP were resected at our institution; clinicopathological data were collected. All of our patients were males, aged 55-80 years. Three cases were cephalic tumors; and one, pancreatic tail tumor, measuring between 2.3 and 5.5 cm. All had neurovascular invasion and lymphatic metastasis. Two had retroperitoneal positive margins. The overall survival (OS) after surgery was three weeks-42 months. Prognosis of ASCP is dark and OS appears to be more closely related to surgical margins status than to other clinicopathological factors.
RESUMO O carcinoma adenoescamoso pancreático (ASCP) é uma variante rara do adenocarcinoma ductal (PDAC). Entre 2004 e 2016, foram ressecados quatro casos de ASCP em nossa instituição, com registro dos dados clínicos e patológicos. Os pacientes eram homens entre 55 e 80 anos. Três tumores eram cefálicos; e um, caudal, com dimensões variáveis entre 2,3 e 5,5 cm. Todos tinham invasão neurovascular e metástases linfáticas; dois, margens cirúrgicas retroperitoneais positivas. A sobrevida global (SG) pós-cirurgia foi de três semanas a 42 meses. O prognóstico do ASCP é sombrio, com SG aparentemente mais relacionada com o status das margens cirúrgicas do que com outro fator clinicopatológico.
ABSTRACT
ABSTRACT Invasive bladder urothelial carcinoma, plasmacytoid variant is a rare entity with scarce cases reported in the literature. We report a case of a 79 years old male, subjected to transurethral resection of bladder tumor, which histological examination revealed a pT1 high-grade urothelial carcinoma. Subsequently, he underwent radical cystoprostatectomy, which showed urothelial carcinoma with lack of cohesion, plasmacytoid variant, positive for citokeratin 7 (CK7), citokeratin 20 (CK20) and trans-acting T-cell-specific transcription factor (GATA-3), and negative for E-cadherin and CD138. It is important to recognize the plasmacytoid variant of the invasive urothelial carcinoma, since it avoids a potential misdiagnosis of metastatic cancer.
RESUMO Carcinoma urotelial invasor da bexiga, variante plasmocitoide, é uma entidade rara, com poucos casos descritos na literatura. Relatamos o caso de um homem, 79 anos, submetido à resseção transvesical de tumor da bexiga, cuja histologia revelou carcinoma urotelial de alto grau pT1. Posteriormente, foi submetido à cistoprostatectomia radical, que mostrou carcinoma urotelial invasor, descoeso, de tipo plasmacitoide, positivo para citoqueratina 7 (CK7), citoqueratina 20 (CK20) e fator de transcrição de ação"trans" específico de células T (GATA-3) e negativo para E-caderina e CD138. É importante reconhecer a variante plasmocitoide do carcinoma urotelial invasor, uma vez que se evita potencial diagnóstico errado de doença metastática.